Curriculum Vitae

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EDUCATION


Sep 2010 – Dec 2014

PhD degree in Ecology and Evolution (summa cum laude)
Institute for Ecology and Evolution, University of Bern, Switzerland
Thesis title: Detecting polygenic selection at different time-scales in human evolution
Supervisors: Prof. Laurent Excoffier and Prof. Marc Robinson-Rechavi

Sep 2008 – Jun 2010

Master of Science degree in Grid Computing (cum laude)
Track Computational Science, variant Bioinformatics
University of Amsterdam, Netherlands
Thesis title: A cell-based model of extracellular-matrix-guided endothelial cell migration during angiogenesis
Supervisors: Dr. Jaap Kaandorp and Dr. Roeland Merks

Mar 1992 – Jun 1995

Bachelor degree in Mathematics Education
Pedagogische Technische Hogeschool, Eindhoven, Netherlands

Sep 1989 – Mar 1992

Architecture student (propedeuse)
Technical University Eindhoven, Netherlands

RESEARCH EXPERIENCE


jun 2017 – PRESENT

Postdoctoral researcher, Princess Maxima Center for Pediatric Oncology
Project title: Cooperative and mutually exclusive genetic alterations in pediatric cancer

Feb 2015 – jun 2017

Postdoctoral researcher, Universitat Pompeu Fabra, Barcelona
Project title: Detecting and understanding the action of natural selection within segmental duplications in primates

ACADEMIC TEACHING EXPERIENCE


MAY 2020

Teacher and Coordinator of Cancer Genomics pilot course, University of Utrecht      Course offered by the Cancer, Stem Cells and Development Biology Master program

SEP 2020 – JUN 2020

Supervisor of Bachelor student, HBO Informatica, Leiden
Internship project: Detecting genetic interactions in childhood brain tumors

MAR 2018 – SEP 2018

Daily supervisor of Master student, MCLS, University of Utrecht
Minor research project: Genetic interactions underlying mutational signatures in paediatric cancer

Aug 2017

Teacher at Summer School Integrated methods to detect polygenic adaptation from genomic data, University of Zurich, Switzerland

Aug 2011 – Nov 2013

Teaching assistant, University of Bern
Courses: Programming and Data Analysis with R, Population genetics

AWARDS & FELLOWSHIPS


OCT 2019

Best Poster Award at UBC Symposium, Utrecht

Feb 2015 – July 2016

Swiss National Science Foundation Early Postdoc.mobility fellowship

Mar 2015

University of Bern, Institute of Ecology & Evolution
Volz Award 2014 (Best PhD Thesis)

Jun 2014

Swiss Institute for Bioinformatics Best Graduate Paper 2014 award

SELECTED SEMINARS AND CONFERENCES


SEP 2019

AACR Meeting Advances in Pediatric Cancer Research, Montreal, Canada
Poster and flash talk: Beyond synthetic lethality: Multiple mechanisms can explain genetic interactions within childhood cancer

Sep 2018

ECCB2018, Athens, Greece
talk: Genetic Interactions in Childhood Cancer

Aug 2017

Symposium Detecting the Genomic Signal of Polygenic Adaptation and the Role of Epistasis in Evolution, University of Zurich, Switzerland
Invited talk: Detection of polygenic selection in primate lineages ancestral to humans

JULY 2017

SMBE2017, Austin, USA
talk: Detecting and understanding the action of natural selection within segmental duplications in primates

July 2016

SMBE2016, Gold Coast, Australia
Organizer of symposium: Structural variations in the light of new sequencing technologies

Sep 2015

Jornada sobre la Evolución Humana, Fundación Valenciana de Estudios Avanzado, Valencia, Spain
Invited talk: Inference of evolutionary forces in human evolution

Jun 2014

SMBE2014, Puerto Rico, USA
Invited talk: Detection of polygenic selection at different evolutionary time scales

Feb 2014

Biology2014, Geneva, Switzerland
Talk: Detection of polygenic selection at different evolutionary time scales

Oct 2013

IBE seminar, Institute for Evolutionary Biology, Barcelona, Spain
Invited talk: Detection of polygenic selection at different evolutionary time scales   

Jan 2013

SIB days, Biel, Switzerland
Talk: Evidence for Widespread Polygenic Adaptation to Pathogens in the Human Genome  

NON-ACADEMIC WORK EXPERIENCE


Aug 2004 – Aug 2008

Mathematics teacher, Planner and Coordinator of Planning department
Weredi secondary school, Valkenswaard, Netherlands

May 2001 – Aug 2004

Software developer
Vespro/ECF Logistics, Eindhoven, Netherlands

Sep 1999 – Apr 2001

Software developer
Lanalyst BV, Sassenheim, Netherlands

Sep 1997 – Sep 1999

Trainer and software developer
BVO information services, Eindhoven, Netherlands

Aug 1996 – Dec 1996

Mathematics teacher
Bisschop Bekkers College, Eindhoven, Netherlands

OTHER SKILLS


Bioinformatics:
Handling and Analysis of Next Generation and Third Generation Sequencing (Pacbio) data sets, Gene set enrichment analysis, Population genetics methods, Genetic Interaction detection

Programming:
R/Bioconductor, C, C++, Python, Perl, Matlab, Mathematica, Bash, Latex, MS Visual Basic, SQL, XML, HTML

Operating systems:
MS Windows, Linux and macOS

Languages:
Dutch: native speaker, English: full professional proficiency,
German and Spanish: good working knowledge, French: basic working knowledge